THE CORPORATE LIBRARY

Related Party Transactions and Outside Related Director Information

Senomyx, Inc. (SNMX)

4/26/2006 Proxy Information

In November 2005, we closed a public offering of our common stock involving investments by certain persons, or groups of affiliated persons, known by us to beneficially own more than 5% of our common stock. The following table provides information regarding the number of shares of common stock purchased in our public offering by these stockholders.

Participant Number of Shares Purchased

Alliance Capital Management L.P. (1) 850,000

T. Rowe Price Associates, Inc. (2) 800,000

Totals 1,650,000

(1) For additional information regarding Alliance Capital Management L.P. and their equity holdings, please see “Security Ownership of Certain Beneficial Owners and Management.”

(2) For additional information regarding T. Rowe Price Associates, Inc. and their equity holdings, please see “Security Ownership of Certain Beneficial Owners and Management.”

During the fiscal year ended December 31, 2005, we granted options to purchase an aggregate of 471,833 shares of our common stock to our directors and executive officers, with exercise prices ranging from $8.60 to $12.85.

Our bylaws provide that we will indemnify our directors and executive officers, and may indemnify other officers, employees and other agents, to the fullest extent permitted by law. Our bylaws also permit us to secure insurance on behalf of any officer, director, employee or other agent for any liability arising out of his or her actions in connection with their services to us, regardless of whether our bylaws permit such indemnification. We have obtained a policy of directors’ and officers’ liability insurance.

We have entered, and intend to continue to enter, into indemnification agreements with our directors and executive officers, in addition to the indemnification provided for in our bylaws. These agreements, among other things, require us to indemnify our directors and executive officers for certain expenses, including attorneys’ fees, judgments, fines and settlement amounts incurred by a director or executive officer in any action or proceeding arising out of their services as one of our directors or executive officers, or any of our subsidiaries or any other company or enterprise to which the person provides services at our request.