RESTATED CERTIFICATE OF INCORPORATION
 
                                       OF
 
                                  MYOGEN, INC.
 
         The undersigned, J. William Freytag, hereby certifies that:
 
         ONE: He is the duly elected and acting President and Chief Executive
Officer of Myogen, Inc.
 
         TWO: The name of the corporation is Myogen, Inc. The date of filing of
its original Certificate of Incorporation with the Secretary of State of the
State of Delaware was May 15, 1998.
 
         THREE: This Restated Certificate of Incorporation restates, integrates
and amends the corporation's Restated Certificate of Incorporation filed on
August 26, 2003 and has been duly adopted in accordance with Sections 242 and
245 of the General Corporation Law of the State of Delaware.
 
         FOUR: The text of the Restated Certificate of Incorporation of this
corporation is hereby amended and restated to read in its entirety as follows:
 
                                       I.
 
         The name of this corporation is MYOGEN, INC.
 
                                      II.
 
         The address of the Corporation's registered office in the State of
Delaware is 2711 Centerville Road, Suite 400, Wilmington, Delaware 19808. The
name of its registered agent at such address is The Corporation Service Company.
 
                                      III.
 
         The purpose of this corporation is to engage in any lawful act or
activity for which a corporation may be organized under the General Corporation
Law of the State of Delaware.
 
                                      IV.
 
         A.       This corporation is authorized to issue two classes of stock
to be designated, respectively, "Common Stock" and "Preferred Stock." The total
number of shares which the corporation is authorized to issue is one hundred
five million (105,000,000) shares. One hundred million (100,000,000) shares
shall be Common Stock, each having a par value of one tenth of one cent
 
                                       1.
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($.001). Five million (5,000,000) shares shall be Preferred Stock, each having a
par value of one tenth of one cent ($.001).
 
         B.       The Preferred Stock may be issued from time to time in one or
more series. The Board of Directors is hereby authorized, by filing a
certificate (a "Preferred Stock Designation") pursuant to the Delaware General
Corporation Law ("DGCL"), to fix or alter from time to time the designation,
powers, preferences and rights of the shares of each such series and the
qualifications, limitations or restrictions of any wholly unissued series of
Preferred Stock, and to establish from time to time the number of shares
constituting any such series or any of them; and to increase or decrease the
number of shares of any series subsequent to the issuance of shares of that
series, but not below the number of shares of such series then outstanding. In
case the number of shares of any series shall be decreased in accordance with
the foregoing sentence, the shares constituting such decrease shall resume the
status that they had prior to the adoption of the resolution originally fixing
the number of shares of such series.
 
                                       V.
 
         For the management of the business and for the conduct of the affairs
of the corporation, and in further definition, limitation and regulation of the
powers of the corporation, of its directors and of its stockholders or any class
thereof, as the case may be, it is further provided that:
 
         A.       1.       The management of the business and the conduct of the
affairs of the corporation shall be vested in its Board of Directors. The number
of directors which shall constitute the whole Board of Directors shall be fixed
exclusively by one or more resolutions adopted by the Board of Directors.
 
                  2.       Subject to the rights of the holders of any series of
Preferred Stock to elect additional directors under specified circumstances,
directors shall be elected at each annual meeting of stockholders for a term of
one year. Each director shall serve until his successor is duly elected and
qualified or until his death, resignation or removal. No decrease in the number
of directors constituting the Board of Directors shall shorten the term of any
incumbent director.
 
                  3.       REMOVAL OF DIRECTORS
 
                           a.       Neither the Board of Directors nor any
individual director may be removed without cause.
 
                           b.       Subject to any limitation imposed by law,
any individual director or directors may be removed with cause by the holders of
two-thirds of the voting power of the corporation entitled to vote at an
election of directors.
 
                  4.       VACANCIES
 
                           a.       Subject to the rights of the holders of any
series of Preferred Stock, any vacancies on the Board of Directors resulting
from death, resignation, disqualification, removal or other causes and any newly
created directorships resulting from any increase in the
 
                                       2.
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number of directors, shall, unless the Board of Directors determines by
resolution that any such vacancies or newly created directorships shall be
filled by the stockholders, except as otherwise provided by law, be filled only
by the affirmative vote of a majority of the directors then in office, even
though less than a quorum of the Board of Directors, and not by the
stockholders. Any director elected in accordance with the preceding sentence
shall hold office for the remainder of the full term of the director for which
the vacancy was created or occurred and until such director's successor shall
have been elected and qualified.
 
                           b.       If at the time of filling any vacancy or any
newly created directorship, the directors then in office shall constitute less
than a majority of the whole board (as constituted immediately prior to any such
increase), the Delaware Court of Chancery may, upon application of any
stockholder or stockholders holding at least ten percent (10%) of the total
number of the shares at the time outstanding having the right to vote for such
directors, summarily order an election to be held to fill any such vacancies or
newly created directorships, or to replace the directors chosen by the directors
then in offices as aforesaid, which election shall be governed by Section 211 of
the DGCL.
 
         B.       1.       BYLAW AMENDMENTS
 
                  Subject to paragraph (h) of Section 43 of the Bylaws, the
Bylaws may be altered or amended or new Bylaws adopted by the affirmative vote
of at least sixty-six and two-thirds percent (66-2/3%) of the voting power of
all of the then-outstanding shares of the Voting Stock of the corporation
entitled to vote. The Board of Directors shall also have the power to adopt,
amend, or repeal Bylaws.
 
                  2.       The directors of the corporation need not be elected
by written ballot unless the Bylaws so provide.
 
                  3.       No action shall be taken by the stockholders of the
corporation except at an annual or special meeting of stockholders called in
accordance with the Bylaws. Following the closing of the Initial Public
Offering, no action shall be taken by the stockholders by written consent.
 
                  4.       Advance notice of stockholder nominations for the
election of directors and of business to be brought by stockholders before any
meeting of the stockholders of the corporation shall be given in the manner
provided in the Bylaws of the corporation.
 
                                      VI.
 
         A.       The liability of the directors for monetary damages shall be
eliminated to the fullest extent under applicable law.
 
         B.       Any repeal or modification of this Article VI shall be
prospective and shall not affect the rights under this Article VI in effect at
the time of the alleged occurrence of any act or omission to act giving rise to
liability or indemnification.
 
                                       3.
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                                      VII.
 
         A.       The corporation reserves the right to amend, alter, change or
repeal any provision contained in this Certificate of Incorporation, in the
manner now or hereafter prescribed by statute, except as provided in paragraph
B. of this Article VII, and all rights conferred upon the stockholders herein
are granted subject to this reservation.
 
         B.       Notwithstanding any other provisions of this Certificate of
Incorporation or any provision of law which might otherwise permit a lesser vote
or no vote, but in addition to any affirmative vote of the holders of any
particular class or series of the Voting Stock required by law, this Certificate
of Incorporation or any Preferred Stock Designation, the affirmative vote of the
holders of at least sixty-six and two-thirds percent (66-2/3%) of the voting
power of all of the then outstanding shares of the voting stock, voting together
as a single class, shall be required to alter, amend or repeal Articles V, VI,
and VII.
 
                            [SIGNATURE PAGE FOLLOWS]
 
                                       4.
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         IN WITNESS WHEREOF, this Certificate has been subscribed this ____ day
of ________, 2003 by the undersigned who affirms that the statements made herein
are true and correct.
 
                                       MYOGEN, INC.
 
                                       By:______________________________________
                                           J. William Freytag
                                           President and Chief Executive Officer
 
                                       5.